McCain, who essentially starts for the Texans as their nickel cornerback, was injured in the first half on Sunday at Tennessee. He had surgery on Monday morning and a screw inserted into his foot.
Teams can designate one injured reserve player to return each season, a new rule that the NFL introduced this year. McCain must sit out for at least for eight weeks but can start practicing after six weeks. That means if he is able to return, it could only be for the Super Bowl.
A fourth-year pro out of Utah, McCain has played in all 12 games with two starts this season. He has 19 tackles, eight passes defensed and one interception.