Head coach Gary Kubiak said Daniels was hurt late in the Sunday night loss at San Francisco, and didn't initially know whether or not the injury would cause his Pro Bowl tight end to miss any playing time.
"Owen Daniels has the fibula that we're getting checked out this afternoon," Kubiak said. "They're doing an MRI on it today. He got hit on one of the last balls he caught."
Kubiak also said Daniels was "real sore today" and that the team's medical training staff was "checking him out."
On the season, the eighth-year veteran has 24 catches for 252 yards and three touchdowns.