Deshaun Watson tossed four touchdowns, wasn't picked off, and when he left the field with 1:50 remaining in regulation, his Texans were on top by seven points.
But the Titans prevailed in Nashville, 42-36, and it was a brilliant quarterbacking display that didn't result in victory for Houston.
"He had a great performance," interim head coach Romeo Crennel said. "He does unbelievable things on the field. He can get out of trouble. It is tough when you're really not able to take advantage of a performance like that. That's the thing we wanted to do. We thought we had a chance to do. But we didn't do. We've got to go back, and hopefully he can have more performances like that, and then defensively we can do a better job to help him out."
After Watson connected with Brandin Cooks for a 1-yard touchdown pass, the Texans led 36-29. Crennel and the Texans went for a 2-point conversion try, but a Watson pass to Duke Johnson was deflected. Watson and the offense walked off the field, and didn't get a chance to get back on it. Tennessee scored the game-tying touchdown at the end of regulation, won the overtime coin toss, and took the first possession the length of the field for another touchdown to win it.
When the proverbial dust settled, Watson completed 28-of-37 passes for 335 yards and finished with the fourth-highest passer rating of his career, at 138.9. The individual heroics meant little to the Pro Bowler, who's team now sits at 1-5 in 2020.
"It's tough," Watson said. "Regardless of how I played, it's all about the W. It's all about winning."
Watson spread the ball around, hitting Cooks, Darren Fells, Will Fuller, V and Randall Cobb for touchdowns. He also ran four times for 26 yards. Losing to the undefeated Titans, in overtime, smarted.
"Every loss is very tough," Watson said. "Being a divisional opponent on the road where we had them, it's even a little bit more tough. This one definitely hurts. But we've got to just keep pushing forward. It's still a long season."
Fells, who finished with a career-best 85 receiving yards on six catches, caught his third score of 2020. He now has 10 touchdown receptions since joining the Texans last season. Fells and the Chiefs' Travis Kelce are the only tight ends in the NFL with at least three touchdown receptions in each of the last four seasons.
"He's always had the ability to extend plays, find the open read, and just make phenomenal plays after that," Fells said. "He's just a phenomenal player and I'm always happy to have him back there leading us."
Watson and the Texans return home for a Week 7 matchup at NRG Stadium with the Packers.
Check out the best photos from Houston Texans @ Tennessee Titans in Week 6.