The Bills went 13-3 last season, winning the AFC East and advancing to the AFC Championship game. It was the club's first division title since 1995.
Buffalo head coach Sean McDermott enters his fifth season in charge, and has a career 38-26 record. The Bills have posted winning records in three of his four previous seasons as head coach.
The last time these two franchises met, Houston stormed back from a double-digit second half deficit and beat Buffalo in overtime for a Wild Card playoff win at NRG Stadium. The Texans have also triumphed in four of the last five regular season showdowns, and are 5-4 against the Bills all-time in the regular season.
Notable Bills: QB Josh Allen, WR Stefon Diggs, WR Cole Beasley, CB Tre'Davious White, LB Tremaine Edmunds
Bills LB Tyrell Adams led the Texans in tackles last season, and played for Houston from 2018-2020. RB Taiwan Jones was a Texan in 2019, and his 34-yard reception against the Bills in overtime setup the game-winning field goal for Houston. Texans defensive lineman Shaq Lawson spent 2016-2019 in Buffalo.