The Texans won both games against Jacksonville in 2020, triumphing 30-14 at home and 29-27 in Jacksonville.
Houston's won eight of the last 10 contests in Jacksonville.
The Jaguars finished fourth in the AFC South last year, going 1-15.
Urban Meyer is the new head coach of the Jaguars, and he won NCAA titles at Florida in 2006 and 2008, and Ohio State in 2014. This is his first NFL coaching job.
The Texans have played Jacksonville 38 times in franchise history, and own a 25-13 record against the Jaguars. Houston's won the last six meetings, and since Week 17 of 2010 is 17-4 in the series. 10 of those 17 victories have been by 10 or more points.
Notable Jaguars: QB Trevor Lawrence, CB Shaquill Griffin, RB James Robinson.
Texans WR Chris Conley caught a combined 87 passes for 1,246 yards and seven scores for Jacksonville in 2019 and 2020.
Jaguars RB Carlos Hyde rumbled for 1,070 yards and six touchdowns with Houston in 2019.