The Texans swept the Jaguars in 2021, dealing out a Week 1 thumping at NRG Stadium, 37-21, and a 30-16 triumph on the road in Jacksonville.
The Jaguars finished fourth in the AFC South last year, going 3-14.
For the second straight year, the Jaguars enter the season with a new head coach. Doug Pederson, who guided the Eagles to a Super Bowl title in the 2017 season, is now in charge. He owns a 42-37-1 career record.
The Texans have played Jacksonville 40 times in franchise history, and own a 27-13 record against the Jaguars. Houston's won the last eight meetings, and since Week 17 of 2010 is 19-4 in the series. 12 of those 19 victories have been by 10 or more points.
Notable Jaguars: QB Trevor Lawrence, DL Travon Walker, RB James Robinson, LB Devin Lloyd
Offensive lineman A.J. Cann started 94 games for Jacksonville between 2015 and 2021. RB Dare Ogunbowale was a Jaguar the last two seasons.