The Texans split the season series with the Jaguars last year, triumphing 13-6 on the road in Week 5, but falling 31-3 at home in Houston on New Year's Day.
Jacksonville won the AFC South last season with a 9-8 record, and fell in the Divisional Round of the playoffs at Kansas City.
2022 was Doug Pederson's first season as the Jags head coach, and he enters Week 3 with a career record of 52-46-1.
The Texans have played Jacksonville 42 times in franchise history, and own a 28-14 record against the Jaguars. Since Week 17 of 2010 Houston is 20-5 in the series. 12 of those 20 victories have been by 10 or more points.
Notable Jaguars: QB Trevor Lawrence, WR Calvin Ridley, RB Travis Etienne, OLB Josh Allen and DL Travon Walker
RB Dare Ogunbowale was a Jaguar in 2020 and 2021, while CB Shaq Griffin played in Jacksonville the last two seasons. Defensive Passing Game Coordinator Cory Undlin was a defensive assistant for the Jaguars from 2009-2011. Jacksonville DT Angelo Blackson played for the Texans from 2017-2019. Jaguars Assistant OL Coach Todd Washington played center and guard for the Texans from 2003-2005.