The Texans swept the Jaguars in 2021, dealing out a Week 1 thumping at NRG Stadium, 37-21, and a 30-16 triumph on the road in Jacksonville.
The Jaguars finished fourth in the AFC South last year, going 3-14.
For the second straight year, the Jaguars enter the season with a new head coach. Doug Pederson, who guided the Eagles to a Super Bowl title in the 2017 season, is now in charge. He owns a 42-37-1 career record.
The Texans have played Jacksonville 40 times in franchise history, and own a 27-13 record against the Jaguars. Houston's won the last eight meetings, and since Week 17 of 2010 is 19-4 in the series. 12 of those 19 victories have been by 10 or more points.
Notable Jaguars: QB Trevor Lawrence, DL Travon Walker, RB James Robinson.
Texans WR Chris Conley caught a combined 87 passes for 1,246 yards and seven scores for Jacksonville in 2019 and 2020. Offensive lineman A.J. Cann started 94 games for Jacksonville between 2015 and 2021. RB Dare Ogunbowale was a Jaguar the last two seasons.
Jaguars Linebacker Tyrell Adams was a Texan from 2018 through 2020, while Cornerback Xavier Crawford was with Houston in 2019.