Tennessee won the AFC South last season by going 12-5. They lost at home in the Divisional Round playoff game to Cincinnati.
In a 2021 Week 11 meeting at Tennessee, Houston triumphed, 22-13. The Titans won the regular season finale, 28-25, at NRG Stadium.
Head coach Mike Vrabel enters his fifth season with Tennessee, and he's 45-26 all-time. He's had a winning record every year. Before his move to Nashville, Vrabel was an assistant in Houston from 2014 through 2017. He coached linebackers the first three years, and was the defensive coordinator for the Texans in 2017.
All-time, the Titans lead the series 22-18. Houston has won 12 of the last 20 meetings.
Notable Titans: RB Derrick Henry, QB Ryan Tannehill, S Kevin Byard, DL Jeffery Simmons
Several Titans spent time with the Texans. Center Ben Jones played from 2012-2015 in Houston. Linebacker Zach Cunningham was a Texan from 2017 through the middle of last season. Fellow Linebacker Dylan Cole was in Houston from 2017 through 2020. Running back Dontrell Hilliard appeared in a pair of games with the Texans in 2020. Kicker Randy Bullock was with the Texans from 2012 through 2015. Defensive Lineman DeMarcus Walker was a Texan in 2021. Defensive Back Lonnie Johnson was a Texan from 2019 through 2021. Defensive Back Terrance Mitchell played in Houston in 2021. Wide receiver Chris Conley played for the Texans in 2021 and earlier this season.