Tennessee went 11-5 last season and won the AFC South. They lost at home in the Wild Card playoff game to Baltimore.
The Titans won both games against Houston in 2020, taking a Week 6 overtime thriller in Nashville, 30-24 and clanging in a last-second field goal in Week 17 to win, 41-38, at NRG Stadium.
Head coach Mike Vrabel is in year four with Tennessee, and he's 29-19 overall. Before his move to Nashville, Vrabel was an assistant in Houston from 2014 through 2017. He coached linebackers the first three years, and was the defensive coordinator for the Texans in 2017.
All-time, the Titans lead the series 21-17. Houston has won 11 of the last 18 meetings.
Notable Titans: RB Derrick Henry, WR A.J. Brown, QB Ryan Tannehill, DE Bud Dupree
Several Titans spent time with the Texans. Center Ben Jones played from 2012-2015 in Houston. Offensive lineman David Quessenberry was drafted by the Texans in 2013 and spent the next five seasons with the team. He was diagnosed with Hodgkin's Lymphoma in 2014, and made his NFL debut late in the 2017 season for Houston. Cornerback Kevin Johnson was Houston's first round draft pick in 2015, and played for the Texans through 2018. RB D'Onta Foreman played for Houston in 2017 and 2018. Tight end MyCole Pruitt played a game for Houston in 2017. Offensive lineman Kendall Lamm spent 2015 through 2018 with the Texans.