Houston's won three of the last five games at Indianapolis.
The Colts went 7-9 and finished third in the AFC South in 2019.
Head coach Frank Reich enters his third season with Indianapolis, and he's 17-15 in two years.
The two teams have met 38 times. The Colts are 29-9 in those contests. Last season, the home team won each game. The Texans defeated Indianapolis, 20-17, in Week 12 on Thursday Night Football.
Notable Colts: QB Philip Rivers, WR T.Y. Hilton, OG Quenton Nelson, LB Darius Leonard, OLB Justin Houston