The Colts were 9-8 and finished second in the AFC South in 2021.
Head coach Frank Reich enters his fifth season with Indianapolis, and his record is 37-28.
The two teams have met 40 times in the regular season. The Colts are 31-9 in those contests. Last season, the Indianapolis swept the two-game series, and they've won seven of the last eight matchups.
Notable Colts: RB Jonathan Taylor, QB Matt Ryan, LB Shaquille (previously went by Darius) Leonard, OG Quenton Nelson, DT DeForest Buckner, CB Stephon Gilmore
Texans Wide Receiver Phillip Dorsett spent 2015 and 2016 in Indianapolis. Defensive Back/Return Man Tremon Smith was a Colt in 2020.