Brian Hoyer won't play against the Jets on Sunday, and T.J. Yates will be the starting quarterback.
Head coach Bill O'Brien ruled the starting signal caller out after Friday afternoon's practice.
Hoyer left Monday night's win over the Bengals late in the third quarter and has been going through the concussion protocol. He didn't practice on Wednesday, Thursday or Friday with the Texans.
O'Brien did say, however, he's optimistic Hoyer will return to practice and play next week.
It's the first reglular season start for Yates since Week 17 of the 2011 season.
He tossed a touchdown to DeAndre Hopkins in the fourth quarter of the win at Cincinnati, and completed 45.5 percent of his passes for 69 yards.
Yates and the Texans kick off against the Jets at noon on Sunday in NRG Stadium.
The Houston Texans roster in photos.
TE, Jordan Akins, #88
WR, Danny Amendola, #89
TE, Antony Auclair, #83
OL, Justin Britt, #68
TE, Pharaoh Brown, #85
RB, Rex Burkhead, #28
OL, Geron Christian Sr., #72
DL, Maliek Collins, #97
WR, Nico Collins, #12
WR, Chris Conley, #18
WR, Brandin Cooks, #13
LB, Zach Cunningham, #41
WR, Davion Davis, #81
QB, Jeff Driskel, #6
K, Ka'imi Fairbairn, #7
DL, Jonathan Greenard, #52
LB, Kamu Grugier-Hill, #51
DB, Vernon Hargreaves III, #26
OL, Charlie Heck, #67
LB, Neville Hewitt, #43
OL, Tytus Howard, #71
RB, Mark Ingram II, #2
DL, Jordan Jenkins, #50
RB, David Johnson, #31
DL, Jaleel Johnson, #93
DB, Lonnie Johnson Jr., #1
P, Cameron Johnston, #11
TE, Brevin Jordan, #9
DB, Desmond King II, #25
LB, Christian Kirksey, #58
RB, Phillip Lindsay, #30
DL, Roy Lopez, #91
DL, Jacob Martin, #54
OL, Justin McCray, #64
QB, Davis Mills, #10
DB, Terrance Mitchell, #39
WR, Chris Moore, #15
DB, A.J. Moore Jr., #33
DB, Jimmy Moreland, #22
DB, Eric Murray, #23
LB, Kevin Pierre-Louis, #57
DL, Charles Omenihu, #94
RB, Scottie Phillips, #27
DB, Justin Reid, #20
OL, Max Scharping, #74
DB, Tremon Smith, #24
DB, Tavierre Thomas, #37
DL, DeMarcus Walker, #55
LB, Garret Wallow, #32
QB, Deshaun Watson, #4
LS, Jon Weeks #46
