Brian Hoyer won't play against the Jets on Sunday, and T.J. Yates will be the starting quarterback.
Head coach Bill O'Brien ruled the starting signal caller out after Friday afternoon's practice.
Hoyer left Monday night's win over the Bengals late in the third quarter and has been going through the concussion protocol. He didn't practice on Wednesday, Thursday or Friday with the Texans.
O'Brien did say, however, he's optimistic Hoyer will return to practice and play next week.
It's the first reglular season start for Yates since Week 17 of the 2011 season.
He tossed a touchdown to DeAndre Hopkins in the fourth quarter of the win at Cincinnati, and completed 45.5 percent of his passes for 69 yards.
Yates and the Texans kick off against the Jets at noon on Sunday in NRG Stadium.
The Houston Texans roster in photos. (Updated 4/16/2021)
TE, Jordan Akins, #88
TE, Antony Auclair
DL, Auzoyah Alufohai, #98
DB, Cornell Armstrong, #30
DL, Ross Blacklock, #90
OL, Justin Britt
DB, Terrence Brooks
TE, Pharaoh Brown, #85
OL, Cohl Cabral, #72
OL, Marcus Cannon
WR, Randall Cobb, #18
DL, Maliek Collins
WR, Chris Conley
WR, Brandin Cooks, #13
WR, Isaiah Coulter, #82
WR, Keke Coutee, #16
DB, Keion Crossen, #35
LB, Zach Cunningham, #41
LB, Tae Davis
DL, Brandon Dunn, #92
LB, Duke Ejiofor, #53
WR, Alex Erickson
K, Ka'imi Fairbairn, #7
QB, Ryan Finley
OL, Hjalte Froholdt, #77
LB, Jonathan Greenard, #52
LB, Kamu Grugier-Hill
LB, Nate Hall, #48
DB, Vernon Hargreaves III, #26
OL, Charlie Heck, #67
RB, Dontrell Hilliard, #27
OL, Tytus Howard, #71
RB, Buddy Howell, #38
RB, Mark Ingram
TE, Ryan Izzo
LB, Jordan Jenkins
RB, David Johnson, #31
DL, Jaleel Johnson
DB, Lonnie Johnson Jr., #32
P, Cameron Johnston
DB, Desmond King
LB, Christian Kirksey
DL, Shaq Lawson
RB, Phillip Lindsay
LB, Jacob Martin, #54
OL, Justin McCray
LB, Whitney Mercilus, #59
DB, Terrance Mitchell
WR, Donte Moncrief
DB, A.J. Moore Jr., #33
WR, Chris Moore
DB, Eric Murray, #23
LB, Hardy Nickerson
DL, Charles Omenihu, #94
DB, Jonathan Owens, #36
LB, Kevin Pierre-Louis
RB, Scottie Phillips, #40
TE, Paul Quessenberry
DB, John Reid, #34
DB, Justin Reid, #20
DL, Derek Rivers
WR, Andre Roberts
DB, Bradley Roby, #21
OL, Max Scharping, #74
DB, Tremon Smith
OL, Jordan Steckler
OL, Lane Taylor
QB, Tyrod Taylor
DL, Vincent Taylor
LB, Joe Thomas
DB, Tavierre Thomas
OL, Cole Toner
OL, Laremy Tunsil, #78
DL, MeMarcus Walker
TE, Kahale Warring, #81
QB, Deshaun Watson, #4
LS, Jon Weeks #46
