Brian Hoyer won't play against the Jets on Sunday, and T.J. Yates will be the starting quarterback.
Head coach Bill O'Brien ruled the starting signal caller out after Friday afternoon's practice.
Hoyer left Monday night's win over the Bengals late in the third quarter and has been going through the concussion protocol. He didn't practice on Wednesday, Thursday or Friday with the Texans.
O'Brien did say, however, he's optimistic Hoyer will return to practice and play next week.
It's the first reglular season start for Yates since Week 17 of the 2011 season.
He tossed a touchdown to DeAndre Hopkins in the fourth quarter of the win at Cincinnati, and completed 45.5 percent of his passes for 69 yards.
Yates and the Texans kick off against the Jets at noon on Sunday in NRG Stadium.
The Houston Texans roster in photos.
DL, Mario Addison, #97
TE, Jordan Akins, #88
DB, Grayland Arnold, #35
DL, Thomas Booker, #56
RB, Rex Burkhead, #28
OL, A.J. Cann, #60
LB, Blake Cashman, #53
DL, Maliek Collins, #96
WR, Brandin Cooks, #13
OL, Austin Deculus, #76
WR, Phillip Dorsett, #4
QB, Jeff Driskel, #6
K, Ka'imi Fairbairn, #7
DB, Jacobi Francis, #38
RB, Royce Freeman, #26
OL, Kenyon Green, #59.
DL, Rasheem Green, #92
DL, Jonathan Greenard, #52
FB, Troy Hairston, #34
LB, Jake Hansen, #49
LB, Christian Harris, #48
OL, Charlie Heck, #67
LB, Neville Hewitt, #43
DL, Kurt Hinish, #93
TE, O.J. Howard, #83
OL, Tytus Howard, #71
DL, Jerry Hughes, #55
P, Cameron Johnston, #11
TE, Brevin Jordan, #9
DB, Desmond King II, #25
LB, Christian Kirksey, #58
DL, Roy Lopez, #91
OL, Justin McCray, #64
QB, Davis Mills, #10
WR, Chris Moore, #15
OL, Jimmy Morrissey, #79
DB, Eric Murray, #23
DB, Steven Nelson, #21
RB, Dare Ogunbowale, #33
DL, Ogbo Okoronkwo, #45
DB, Jonathan Owens, #36
DB, Jalen Pitre, #5
OL, Scott Quessenberry, #54
TE, Teagan Quitoriano, #84
LB, Jalen Reeves-Maybin, #44
WR, Amari Rodgers, #19
DB, Tremon Smith, #1.
DB, M.J. Stewart, #29
DB, Tavierre Thomas, #37
OL, Laremy Tunsil, #78
LB, Garret Wallow, #32
LS, Jon Weeks #46
