Kendrick Lewis picked off Andrew Luck in the first quarter, and returned it 27 yards for a score.
On 3rd-and-9 at their own 16-yard line, Luck threw a pass to the left side for tight end Coby Fleener. But Lewis jumped the route and ran it back for the touchdown.
Check out these snapshots of the Texans getting ready for their Week 15 contest at Indianapolis.
It was the third interception of the season for Lewis, and it was the fifth defensive touchdown of 2014 for the Texans. Those five defensive scores are tieed for the most in franchise history with the 2004 defense.
The Lewis interception was also the 30th takeaway of the year for Houston, which is tied for the best mark in team history with the 2011 squad.
The touchdown gave the Texans a 7-0 lead at the 5:56 mark of the opening quarter.