Arian Foster, Kareem Jackson, and Johnathan Joseph all remain day-to-day after suffering injuries in Sunday's 31-21 loss to the Philadelphia Eagles.
Foster exited the game in the third quarter after being hurt on a non-contact play. O'Brien said the All-Pro back did not undergo an MRI when asked about his groin injury.
"No, nothing new," O'Brien said when asked about Foster's status Monday.
The cornerback duo of Jackson and Joseph left the game early in the first quarter and also did not return. Joseph was evaluated for a concussion and returned to the sideline to watch the rest of the game.
Jackson reportedly suffered a knee injury, a claim that O'Brien refuted in his Monday press conference.
"No, I didn't say anything about a knee," O'Brien said. "You didn't hear that from me."
When pushed on the issue, O'Brien joked that Jackson had "a toothache." The Texans head coach has not been a fan of commenting on player injuries primarily due to player privacy and team strategy.
"They definitely will be day-to-day," O'Brien said. "They will be guys that we have to check in with every day, especially with the nature of what their injuries are so we'll just kind of see how they are tomorrow and the next day. I think the bye is coming at a good time for that."
The (4-5) Texans have a bye on Sunday and will face the Browns in Cleveland in Week 11.