DeAndre Hopkins is now the franchise's single season leader in touchdown catches.
With a 19-yard scoring reception in the fourth quarter, Hopkins pulled down his 10th of 2015.
Hopkins came down with three receptions on that drive, which saw the Texans march 83 yards in six plays, and burn 2:46 off the game clock.
Andre Johnson caught nine touchdowns in 2009.
Hopkins had five catches for 88 yards at that point in the ballgame.
The Texans faced the Bills at Ralph Wilson Stadium in Week 13.