Houston's split the last six games with the Colts at Indianapolis.
The Colts were 11-5 and finished second in the AFC South in 2020. They fell in the Wild Card round at Buffalo.
Head coach Frank Reich enters his fourth season with Indianapolis, and he's 28-20 in three years.
The two teams have met 40 times. The Colts are 31-9 in those contests. Last season, the Indianapolis swept the two-game series.
Notable Colts: LB Darius Leonard, RB Jonathan Taylor, QB Carson Wentz, WR T.Y. Hilton, OG Quenton Nelson, DT DeForest Buckner